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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Fast Track, 2002
    The role of the DJ-1 gene in early-onset recessive Parkinson's Disease (PARK7)

    Several families with rare genetic forms of Parkinson's disease have been identified, and at present mutations in three genes implicated in familial forms of parkinsonism have been described: the...

  • Cell Line, 2002
    Development of a Stem Cell Replacement Therapy for Parkinson's Disease: Induction of Midbrain DA Neurons from ES Cells

    In the present project three groups at the Karolinska Institute join forces in order to: 1) Identify molecular players capable of inducing a midbrain dopaminergic (DA) phenotype. We previously found...

  • Cell Line, 2002
    Development and Utilization of Dopaminergic Cell Lines for the Treatment of Parkinson's Disease

    We have recently succeeded in differentiating adult human and animal bone marrow stromal stem cells (BMSCs) into neurons (nerve cells). A subpopulation of the neurons activates functions that are...

  • Cell Line, 2002
    Development & characterization of adult substantia nigra derived neural progenitor cells

    There is growing evidence that certain areas of the adult central nervous system retain the capacity to generate new neurons from endogenous immature progenitor cells. Our preliminary results show...

  • Cell Line, 2002
    Establishing stable lines of human nigral dopaminergic progenitor cells

    We intend to develop lines of clonal, stable and self-renewing human dopamine-producing neuronal progenitor cells. These will be derived from the part of the midbrain that gives rise to dopamine...

  • Cell Line, 2002
    Dopamine Neurons Derived from Human ES Cells

    Embryonic stem (ES) cells proliferate extensively, and preliminary data show that animal ES cells can be manipulated to generate highly enriched populations of dopamine neurons that express genes...

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