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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Cell Line, 2002
    Generation of Functional Dopamine Neurons of Human Origin for Grafting in Parkinson's Disease

    The project will use multipotent neural stem cells as starting material. These cells, which reside in the central nervous system, will be isolated from the developing brains of five- to eight-week-old...

  • Fast Track, 2001
    Lentiviral Delivery of Neublastin to MPTP-Treated Pre-clinical models

    Parkinson's disease (PD) results primarily from striatal dopamine (DA) insufficiency and degeneration of dopaminergic neurons within the substantia nigra pars compacta. The cause of PD still remains...

  • Fast Track, 2001
    Rapid Parkinson's Drug Screen Using Parkin Knockout Stem Cells

    Autosomal recessive loss-of-function mutations in the parkin gene are the most common cause of familial Parkinson's disease (PD), which is characterized by selective loss of dopaminergic (DA) neurons...

  • Fast Track, 2001
    PET Neuroimaging Study of the Brain Serotonin Transporter in Parkinson's Disease: Relationship to Clinical Depression

    Approximately 40% of patients with Parkinson's disease (PD) suffer from depression, which in many cases is more disabling than the impairment of motor function. Since the original discovery by Oleh...

  • Fast Track, 2001
    Generation and Analysis of Conditional Pre-Clinical Model Mutants for BNDF and GDNF Receptors

    Parkinson's disease results largely from the degeneration of dopamincergic neurons in the substantia nigra pars compacta. The reason for the successive death of these neurons is not known so far...

  • Fast Track, 2001
    rAAV-ribozyme Mediated Parkin Knockdown as a Pre-clinical Model of Parkinson's Disease

    Parkinson's disease is characterized by a series of debilitating motor abnormalities that worsen over time. The motor symptoms of Parkinson's disease are largely the result of the specific progressive...

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