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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2013
    Comprehensive Structural and Molecular Phenotyping of Parkinson’s Disease Models

    Objective/Rationale:             
    Parkinson’s disease (PD) pre-clinical models carrying relevant human PD gene mutations can provide important insights into the molecular mechanisms implicated in PD...

  • LRRK2 Cohort Consortium Resource Request, 2013
    Peripheral Blood-based Transcript Biomarkers for Prediction of Parkinson Disease in LRRK2 Mutation Carriers

    Objective/Rationale:             
    Currently, there is no known marker that can be found in the human blood that can help to predict Parkinson's disease (PD). There is also no marker that can help...

  • LRRK2 Pharmacodynamic Assays, 2013
    Fluorescence Fluctuation Spectroscopy Assays to Monitor the Activity of LRRK2

    Objective/Rationale:             
    LRRK2 is a major protein target for therapeutic treatment of Parkinson’s disease (PD). The lack of assays (experiment set-ups) available for measuring the activity of...

  • LRRK2 Cohort Consortium Resource Request, 2013
    Analysis and Replication of a Genetic Interaction between LRRK2 and PARK16

    Study Rationale:
    We previously showed that variants in two known Parkinson’s disease (PD) genes, LRRK2 and PARK16, genetically interact to increase risk of disease. Learning more about genetic variants...

  • LRRK2 Cohort Consortium Resource Request, 2013
    Cortical and Subcortical Changes in Non-manifesting Carriers of the G2019S Mutation in the LRRK2 Gene

    Objective/Rationale:
    Imaging techniques such as DaT SPECT, FDG PET and magnetic resonance imaging (MRI) have frequently been used to assess Parkinson’s disease (PD) changes in parts of the brain called...

  • LRRK2 Cohort Consortium Resource Request, 2013
    Influence of Immune Subtypes on the LRRK2 Phenotype

    Study Rationale:
    There is growing evidence for a relevant influence of chronic and subtle inflammation on Parkinson’s disease (PD). The most common causes of monogenic (involving one gene) PD are...

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