The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Understanding LRRK2 Biology, 2010Biochemical characterization of full length human recombinant LRRK1 and LRRK2
Promising Outcomes of Original Grant:
In our initial application we proposed to take advantage of a lentiviral system recently developed in KULeuven to express full-length, soluble human LRRK1 and... -
Research Grant, 2010Longitudinal Follow-Up of Clinical and Neuroimaging Signs and Biomarkers in Symptoms & Side Effects and aSymptoms & Side Effects LRRK2 Mutation Carriers in Comparison to Idiopathic PD and Controls
Objective/Rationale:
Parkinson’s disease (PD) is a common neurodegenerative disease that leads to progressive motor impairment as well as autonomic and cognitive disturbances. The cause of most of... -
MJFF Research Grant, 2010LRRK2 G2019S Disease Penetrance Modifiers
Objective/Rationale:
The most commonly found mutation in Parkinson’s disease patients is LRRK2 G2019S. This mutation can lead to the development of Parkinson’s disease at very different ages, from... -
MJFF Research Grant, 2010Characterization of an Inhibitor Compound of LRRK2 Function
Objective/Rationale:
LRRK2 (Leucine-Rich Repeat Kinase 2) is a protein thought to be involved in regulating signaling pathways in cells. Mutations in the gene for LRRK2 are associated with some... -
Rapid Response Innovation Awards, 2011Direct Reprogramming of Cells into Dopamine Neurons
Objective/Rationale:
The availability of dopaminergic neurons for in-depth study or therapeutic replacement approaches has traditionally been limited. We aim to reprogram cells into dopaminergic... -
Rapid Response Innovation Awards, 2011Whole Exome Sequencing in an Amish Parkinson's Disease Pedigree
Objective/Rationale:
Although there is strong evidence to suggest genetics plays a role in Parkinson’s disease, the majority of the genes involved in Parkinson’s disease remain unidentified. We...
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Our funding programs support basic, translational and clinical research from academia and industry.