The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Therapeutic Pipeline Program, 2017Protein Homeostasis and the Ubiquitination Pathway in Parkinson's Disease
Study Rationale:
Parkinson's disease (PD) involves accumulation of toxic proteins in cells in specific areas of the brain. These cells normally have protective mechanisms to remove these toxic... -
Research Grant, 2017Development of Analytic Tests to Use as Nilotinib Companion Diagnostics in Parkinson's Disease
Study Rationale:
Evidence suggests that increased activity of the c-abl protein in the brain may contribute to the development and progression of Parkinson's disease (PD). Nilotinib, a drug that... -
Research Grant, 2017White Blood Cell and Urine Collection in LRRK2 and GBA Mutation Carriers
Study Rationale:
Mutations in the LRRK2 and GBA genes increase the risk for Parkinson's disease (PD). The mechanism by which these mutations increase PD risk is unknown. One potential explanation may...
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Therapeutic Pipeline Program, 2017Small-Molecule Pharmacological Chaperones Reverse Alpha-synuclein-impaired Debris Removal
Study Rationale:
The goal of this project is to find therapeutic drugs for Parkinson's disease (PD) that target alpha-synuclein, a key player in PD. We propose that the negative impact of alpha...
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LRRK2 Biology Consortium, 2017Characterization of Leukocytes as Biomarkers for LRRK2 and Autophagy in Parkinson's Disease
Study Rationale:
To avoid accumulation of products that may cause toxicity, neurons rely on a series of highly efficient mechanisms of quality control. It has been proposed that, in those with...
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Target Advancement Program, 2017Neuroprotective Effects of Endosulfine-alpha in Parkinson's Disease
Study Rationale:
Evidence suggests that alpha-synuclein can cause neuron death in Parkinson's disease (PD) by forming clusters (or aggregates) on the surface of small structures inside the cell called...
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Our funding programs support basic, translational and clinical research from academia and industry.