The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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LRRK2 Pharmacodynamic Assays, 2013LRRK2-associated Mitochondrial DNA Damage as a Phenotype for Unbiased Screening
Objective/Rationale:
The normal functions of LRRK2 are poorly understood, and the mechanism(s) by which LRRK2 mutations cause PD are unclear. Also, therapeutic development has been hampered by the... -
Biosample and Tissue Resource, 2013Is Dysphagia in Parkinson’s Disease Caused by Lewy Pathology in the Upper Aerodigestive Tract?
Objective/Rationale:
We have recently demonstrated that the nerves supplying the throat are directly affected in Parkinson’s disease (PD) by the same microscopic process that affects the... -
Research Grant, 2013Virtual Research Visits
Objective/Rationale:
The Michael J. Fox Foundation’s Fox Trial Finder is designed to facilitate and increase the participation of individuals with Parkinson’s disease in clinical trials... -
Research Grant, 2013Long-term Cortical Recording in Parkinson’s Disease Patients Using a Totally Implanted Device
Objective/Rationale:
Deep brain stimulation (DBS) of basal ganglia structures is an effective treatment for Parkinson’s disease (PD). However, its mechanism of action is still unclear... -
Research Grant, 2013DNA Methylation Profiling from Blood as a Source for Biomarker Discovery in Parkinson’s Disease
Objective/Rationale:
Epigenetic mechanisms regulate when the information stored in the DNA is expressed to ensure the proper function of the cells, including neurons in the brain. Recent... -
Research Grant, 2013Advancement of Quantitative Disease Progression Modeling of Parkinson’s Disease
Objective/Rationale:
In clinical trials, the progression of Parkinson’s disease (PD) is primarily measured by the change in total Unified Parkinson Disease Rating Scale (UPDRS) score...
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Our funding programs support basic, translational and clinical research from academia and industry.