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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • LRRK2 in the Immune System, 2012
    The Four Horsemen of G2019S

    Objective/Rationale:             
    Using stem cell-derived neurons from individuals with Parkinson’s disease, we have found that dopaminergic neurons carrying the G2019S variant of LRRK2 are abnormally...

  • MJFF Research Grant, 2012
    Investigation of Possible Pathological Changes in Aged LRRK2 Knockout Models

    Objective/Rationale:             
    To determine if there are any pathological changes in either the brain, kidney, lung, spleen, liver, and heart in aged LRRK2 knockout and wild type pre-clinical...

  • MJFF Research Grant, 2012
    Role of LRRK2 in Alpha-Synuclein-Induced Neurodegeneration

    Objective/Rationale:
    This project seeks to develop a robust and standardized pre-clinical model relevant to late-onset Parkinson’s disease (PD) that will identify clinically viable LRRK2 kinase...

  • Therapeutics Development Initiative, 2012
    Peripheral Administration of XPro1595 in the Pre-clinical 6-OHDA Model of Parkinson's Disease

    Objective/Rationale:
    Inflammation in the brain is one of the causes of Parkinson’s disease.  XPro1595 is a selective inhibitor of soluble TNF that “turns off” inflammation to stop the loss of...

  • Rapid Response Innovation Awards, 2012
    A Pair of Neurotrophic Factor Inducing Drug Candidates

    Objective/Rationale:             
    The brain makes proteins that are required to keep nerve cell alive and healthy.  They go down in Parkinson’s disease, and cannot get into the brain when ingested. ...

  • LRRK2 Cohort Working Group, 2012
    LRRK2 Mutations and Cancer Risk

    Objective/Rationale:             
    Two groups have reported a possible association between carrying a LRRK2 mutation and non-skin cancers.  In order to determine whether this finding is present in a...

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