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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2012
    Role of Brain-specific PGC-1Alpha Isoforms in Parkinson's Disease

    Objective/Rationale:             
    Impaired mitochondrial function and enhanced oxidative stress play a major role in the pathogenesis of Parkinson’s disease (PD). PGC-1alpha is a transcriptional...

  • LRRK2 in the Immune System, 2012
    LRRK2 Regulates Host Response to Microbial Infections

    Objective/Rationale:             
    We recently formed a research team that comprises Parkinson’s scientists, immunologists, Crohn’s disease experts, virologists and pathologists; this, to explore a...

  • MJFF Research Grant, 2012
    Establishing LRRK2 Signaling Pathways

    Objective/Rationale:             
    Inherited mutations that cause Parkinson’s disease have been studied with earnest since their discovery beginning in the 1990’s.  These genetic alterations point us...

  • MJFF Research Grant, 2012
    Evaluation of PD-linked Transcripts in PPMI

    Objective/Rationale:             
    Confirm associations between the expression of three susceptibility genes and Parkinson’s in peripheral blood of individuals with early-stage, untreated disease, and...

  • MJFF Research Grant, 2012
    In Vivo Characterization of Helper-dependent Adenoviral Vectors Expressing Human LRRK2

    Objective/Rationale:             
    Mutations in the LRRK2 gene are a common cause of familial Parkinson’s disease. Familial LRRK2 mutations induce neuronal toxicity in vitro. Reliable pre-clinical...

  • Neurotrophic Factors Challenge, 2012
    Novel Cell-based Strategy for GDNF Delivery in Parkinson's Disease

    Objective/Rationale:             
    Glial cell line-derived neurotrophic factor (GDNF) is the most potent nerve cell growth molecule capable of protecting the dopamine neurons that are affected in...

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Our funding programs support basic, translational and clinical research from academia and industry.

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