The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2011Fractalkine-CX3Cr1 Signaling in Models of Parkinson Disease: Quest for Novel Therapeutic Strategies
Objective/Rationale:
Microglia, one of the key players in neuroinflammation, are increased in number and activated in the brains of Parkinson’s disease (PD) or pre-clinical models of PD. A recent... -
Rapid Response Innovation Awards, 2011The Development of Novel Adeno-associated Virus Vectors for Intravenous Parkinson's Gene Therapy
Objective/Rationale:
As Parkinson disease progresses, a wide range of brain areas exhibit evidence of inflammation and degeneration, but presently no therapies exist that selectively target these... -
Rapid Response Innovation Awards, 2011Developing and Characterizing Anti-Alpha-Synuclein Nanobodies from an Immune Phage Display Library
Objective/Rationale:
This project uses a novel approach to deal with alpha-synuclein, which accumulates abnormally in Parkinson’s disease (PD). Cutting-edge recombinant antibody technologies will... -
Rapid Response Innovation Awards, 2011Ability of a Mitochondria Improver, Berberine, to Attenuate Parkinson's Disease
Objective/Rationale:
Mitochondrial dysfunction is a central modification underlying the damage of dopamine neurons in Parkinson’s disease (PD). Our hypothesis is that drugs able to stabilise... -
Rapid Response Innovation Awards, 2011Alpha-synuclein May Be Responsible for the Link Between Parkinson's Disease and Melanoma
Objective/Rationale:
Although the association between Parkinson’s disease (PD) and melanoma has been well established, biological explanations are still lacking. PD-causing gene alpha-synuclein is... -
MJFF Research Grant, 2011Identification of Nrf2 Activators Using an In Silico Modeling Platform, Followed by Evaluation of These Compounds in an Alpha-Synuclein Model of PD
Objective/Rationale:
Oxidative stress has been implicated in the etiology of Parkinson’s disease (PD). Under such conditions, the transcription factor NF-E2-related factor (Nrf2) binds to antioxidant...
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Our funding programs support basic, translational and clinical research from academia and industry.