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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2010
    Clinical Assessment of Patients with PD Who Underwent DAT Scan and FDG PET at the Early Stages of Their Extra-Pyramidal Disorder as Part of Their Initial Workup

    Objective/Rationale: 
    Ashkenazi Jewish PD patients in Israel have a 14% chance of carrying the G2019S LRRK2 mutation and 18% of carrying mutations in the GBA gene. Little is known on the association...

  • MJFF Research Grant, 2010
    Technology for Clinicogenetic Studies of LRRK2 G2019S in Tunisia

    Objective/Rationale:
    We seek to create and enhance a secure database, accessible by collaborators with customizable, user-friendly, web-based entry for clinical, genetic and pedigree information. This...

  • MJFF Research Grant, 2009
    Clinicogenetic Studies of LRRK2 G2019S in Tunisia

    Objective/Rationale:
    Parkinson’s disease (PD) is a prevalent, heterogeneous disorder with a complex, multifactorial etiology. In Tunisia, North Africa, the burden of genetically-defined LRRK2 G2019S...

  • Novel Approaches to Drug Discovery for Parkinson's Disease, 2007
    Fisetin and Derivatives as Neuroprotective Drugs for the Treatment of Parkinson's Disease

    Objective/Rationale: 

    Glutathione (GSH) is an antioxidant produced naturally by cells thereby providing them with a defense against oxidative stress. There is good evidence that GSH levels decrease in...

  • PPMI Data Challenge, 2016
    Multivariate Prediction of Parkinson's Disease Clinical Progression (2016 PPMI Data Challenge Winner)

    Study Rationale:
    Parkinson's disease (PD) is heterogeneous in both clinical representation and prognosis, as indicated by a large diversity of rates of progression in motor as well as non-motor...

  • LRRK2 in the Immune System, 2012
    Does Peripheral Immune Challenge Exacerbate LRRK2-Induced Neuronal Pathology?

    Objective/Rationale:             
    Neuro-immune interactions may have etiological roles in the development of several neurodegenerative disorders. LRRK2 is a cell signaling protein and when mutated, is...

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