The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Clinical Intervention Awards, 2010Maintenance of Continuous Plasma Levodopa Levels through Continuous Subcutaneous Carbidopa Administration
Objective/Rationale:
In Parkinson’s disease (PD) therapeutics, carbidopa is used together with levodopa to prevent its breakdown. This investigation will determine whether subcutaneous carbidopa... -
Rapid Response Innovation Awards, 2010Biomarkers and Immunotherapy for Parkinson's Disease
Objective/Rationale:
We theorize that the interplay between the immune system and the brain plays a substantive role in the progression of Parkinson’s disease. Moreover, we posit that the immune system... -
Rapid Response Innovation Awards, 2010Mechanism and Modulation of Alpha-Synuclein Expression
Promising Outcomes of Original Grant:
In the initial grant, we tested the hypothesis that GATA-2 is a direct regulator of alpha-synuclein expression in dopaminergic neurons and therefore represents a... -
Rapid Response Innovation Awards, 2010In Vivo Assessment of Alpha-Synuclein Secretion
Objective/Rationale:
Recent data from our lab (Emmanouilidou et al, 2010) suggest that cell-produced physiologically secreted alpha-synuclein can cause the death of neuronal recipient cells. Although... -
MJFF Research Grant, 2010Regulated rAAV-GDNF to treat Parkinson's disease: Translational research plan
Objective/Rationale:
We are attempting to perfect gene therapy using glial cell line-derived neurotrophic factor (GDNF) for Parkinson’s disease. One part of developing this gene therapy is... -
Neurotrophic Factor Therapies for Parkinson's Disease, 2010CDNF (Cerebral Dopamine Neurotrophic Factor) for Therapy of Parkinson's Disease
Objective/Rationale:
CDNF protein is expressed in human brain, acts differently from known neurotrophic factors and can protect and repair dopamine neurons in two pre-clinical models of Parkinson’s...
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Our funding programs support basic, translational and clinical research from academia and industry.