The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Rapid Response Innovation Awards, 2009Development of Potent Conformation-Specific Compounds Directed to Monomeric Alpha-Synuclein
Promising Outcomes of Original Grant:
The goal of our original funded grant was to use our alpha-synuclein assay to identify compounds that prevent conformational change to the fully open form of the... -
Rapid Response Innovation Awards, 2009Evaluation of a Viral Non-coding RNA as a Neuroprotective and Neurorestorative Therapy in Chronic Models of Parkinson's Disease
Promising Outcomes of Original Grant:
Previously, we asked whether a novel viral non-coding RNA (an RNA which does not appear to encode a protein), but with known pro-life functions, could act to... -
MJFF Research Grant, 2009N-Acetylcysteine CSF Levels and Biomarkers in a Pre-clinical Model of PD
Objective/Rationale:
N-Acetylcysteine (NAC) is an orally absorbed compound that supports neuronal synthesis of glutathione, a key neuronal antioxidant. Our objective here is to establish the blood and... -
Rapid Response Innovation Awards, 2009Generation of Dorsal Motor Nucleus (DMN) Specific Pre-clinical Model of Alpha-Synuclein Overexpression to Study Etiology of Autonomic Dysfunction in PD
Promising Outcomes of Original Grant:
According to Braak Staging of PD Pathology, the dorsal motor nucleus (DMN) is one of the earliest brain nuclei that accumulate alpha-Synuclein (aSyn) pathology... -
MJFF Research Grant, 2009Neoangiogenesis and blood-brain barrier in L-DOPA-induced dyskinesia
Promising Outcomes of Original Grant:
Working on a pre-clinical model of Parkinson´s disease, we have found that levodopa treatment induces proliferation of endothelial cells and angiogenesis in the... -
MJFF Research Grant, 2009Specific Inhibition of Nucleation of Alpha-Synuclein Aggregation as a Therapeutic Strategy
The discovery of specific genes associated with rare, genetic forms of Parkinson’s disease has opened the opportunity to investigate the mechanisms of the disease and to develop novel drugs. Parkinson...
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Our funding programs support basic, translational and clinical research from academia and industry.