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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Understanding LRRK2 Biology, 2009
    Building a LRRK2 Cohort Core Database

    Objective/Rationale
    MJFF is funding the expansion of two international LRRK2 cohorts to gain insight into the relationship of this genetic mutation to Parkinson’s disease.  Within each funded study...

  • Target Validation, 2009
    Testing PDE-1 Inhibitor in MPTP-treated Macaques

    Promising Outcomes of Original Grant:
    Our goal is to develop novel therapeutic molecules that promote normal dopamine neurotransmission in the brain affected by PD. We hypothesize that these molecules...

  • MJFF Research Grant, 2009
    The Validation of Anxiety Scales in Parkinson's Disease

    Objective/Rationale:
    This study has two objectives:
    1. To assess the occurrence and symptoms of anxiety disorders in Parkinson's disease, including atypical anxiety syndromes, and anxiety states...

  • Novel Approaches to Drug Discovery for Parkinson's Disease, 2009
    Inhibition of Brain-Dependent Nitric Oxide (NO) Over-Production by Isoform-Selective NO Synthase (NOS) Inhibitors

    Objective/Rationale: 
    The project objective is to test whether custom-designed, small-molecule, isoform-selective NOS inhibitors can reduce brain and systemic nitric oxide levels and show improved...

  • Novel Approaches to Drug Discovery for Parkinson's Disease, 2009
    Development of HSF1 Effectors as Parkinson's Disease Therapeutics

    Objective/Rationale:
    This project will focus on the development of small molecule therapeutics to treat Parkinson’s disease by advancing lead compounds that modulate protein chaperones. Protein...

  • Novel Approaches to Drug Discovery, 2009
    Optimizing Metalloporphryins for Clinical Development

    Objective/Rationale:
    Oxidative stress is a well-defined therapeutic target for Parkinson’s disease (PD) and antioxidant therapy is one of the most promising neuroprotective strategies for its...

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Our funding programs support basic, translational and clinical research from academia and industry.

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