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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • MJFF Research Grant, 2010
    Parkinson's Disease NeuroEPIC: A Study of Genes and the Environment

    Objective/Rationale: 
    We will take advantage of the large European Prospective Investigation in Cancer (EPIC), a unique resource involving almost 500,000 participants from 10 European countries, with...

  • Rapid Response Innovation Awards, 2010
    Ghrelin - a Peripheral, Preclinical Biomarker for Parkinson's Disease

    Promising Outcomes of Original Grant:
    In our original grant we investigated serum concentrations of the hormone ghrelin in the fasting state and at different time points after a standardized test meal...

  • Biomarkers, 2009
    Development of an alpha6*-Selective Neuronal Nicotinic Receptor (NNR) Imaging Agent as a Parkinson's Disease Biomarker

    Objective/Rationale
    The availability of a selective PET radiotracer for the drug target is critical for determining receptor occupancy in humans. NNR subtypes containing the alpha? subunit have been...

  • LRRK2 Cohort Consortium, 2013
    Gender Differences in LRRK2 Mutation and Non-LRRK2 Mutation PD, and Expression of LRRK2 Mutations

    Objective/Rationale:
    In Western populations, men are approximately 1.5 times more likely to develop Parkinson’s disease (PD) than women. Furthermore, epidemiologic and clinical features of PD vary...

  • Postural Instability and Gait Disturbances, 2009
    Role of the Posterior Parietal Cortex and Pedunculopontine Nucleus in the Pathophysiology of Freezing of Gait: An MRI and TMS Study

    Objective/Rationale:
    Although disturbances in the posterior parietal cortex (PPC) and pedunculopontine nucleus (PPN) are thought to be involved in the development of freezing of gait (FOG) in PD...

  • Improved Neuromodulation Approaches, 2014
    Adaptive Closed Loop Neuromodulation and Neural Signatures of Parkinson’s Disease

    Study Rationale:
    Currently deep brain stimulation (DBS) is limited to “open-loop” stimulation, without real-time adjustment to the patient’s state of activity, fluctuations and types of motor symptoms...

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