The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
-
Biomarkers, 2009High Resolution Diffusion Tensor MRI Imaging as a Biomarker of Parkinson's Disease Diagnosis and Disease Progression
Objective/Rationale:
As Parkinson’s disease (PD) is moving into the era of neuroprotective interventions one of the major objectives is the development of a biomarker of PD diagnosis. This study... -
MJFF Research Grant, 2008Developing New Antibodies for a Standardized Alpha-Synuclein Assay (ELISA)
Objective/Rationale:
To raise and characterize new antibodies in vertebrate animals that allow for the routine measurement of a key protein linked to Parkinson disease, alpha-synuclein. A renewable... -
Rapid Response Innovation Awards, 2008Development of modulators of alpha-synuclein conformation for PD therapeutics
Promising Outcomes of Original Grant:
Our Rapid Response Innovation Award (RRIA) enabled us to develop a conformational change assay for monomeric alpha-synuclein. We identified positive and negative... -
MJFF Research Grant, 2008Pharmacodynamic Biomarkers of Drug-induced Protein Clearance in Rodent Cerebrospinal Fluid
Objective/Rationale:
Parkinson’s disease is, at least in part, a disease caused by misfolding and aggregation of the protein alpha-synuclein. Boosting the natural degradation machinery of diseased... -
Therapeutics Development Initiative, 2008Discovery of Novel Inhibitors of LRRK2 for the Treatment of Parkinson's Disease
Objective/Rationale:
A recent breakthrough in Parkinson’s disease research is the discovery that mutations in the gene for leucine-rich repeat kinase 2 (LRRK2) are associated with both the hereditary... -
Therapeutics Development Initiative, 2008GPR88, a new PD target involved in the modulation of basal ganglia circuitry
The receptor GPR88 is highly expressed in brain areas relevant for Parkinson's disease. GPR88 is an orphan receptor, i.e., a receptor with no known ligands. The neurobiological role and signalling...
Apply for a Grant
Our funding programs support basic, translational and clinical research from academia and industry.