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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Rapid Response Innovation Awards, 2008
    Screen for Drugs to Reduce ER Stress

    Objective/Rationale:
    Humans are exposed to agents and conditions that cause stress to dopaminergic neurons. Neurons can survive stress by modulating the biosynthesis and degradation of proteins within...

  • Rapid Response Innovation Awards, 2008
    DNA Methylation as an Epigenetic Mechanism in the Etiopathogenesis of Parkinson's Disease

    Objective/Rationale:
    The objective of this research is to determine whether epigenetic factors play a role in the development of sporadic Parkinson’s disease. Epigenetic factors are chemical...

  • Rapid Response Innovation Awards, 2008
    Generating Patient-Specific Induced Pluripotent Stem Cells to Study Parkinson's Disease

    Objective/Rationale:
    One of the major hurdles for Parkinson’s research is the lack of live dopamine neurons from patients for long-term studies and drug screens. This project will use the newly...

  • Rapid Response Innovation Awards, 2008
    Posiphen as a Well-tolerated Alpha-synuclein Inhibitor and a Potential 5'UTR Directed Drug Treatment of Parkinson's Disease

    Objective/Rationale:
    An inter-relationship exists between the Parkinson’s disease-related protein alpha-synuclein and the Alzheimer’s Aß-amyloid plaque protein. Phenserine reached clinical assessment...

  • Rapid Response Innovation Awards, 2008
    The Role of the Unfolded Protein Response (UPR) in Parkinson's Disease

    Objective/Rationale:
    Our general objective is to investigate the role of the cellular stress responses linked to organelle damage such as the Unfolded Protein Response in the development of Parkinson...

  • Rapid Response Innovation Awards, 2008
    A Novel Cell Model for LRRK2 Parkinson's Disease

    Objective/Rationale:
    The aim of this project is to create a model of Parkinson’s disease using skin cells from  patients who have an inherited form of Parkinson’s disease. Using newly developed stem...

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