The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
Search or browse funded studies
Previously funded studies appear chronologically, with the most recent appearing first.
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Target Validation, 2006Lentivirally-Delivered GRK2 and GRK6 for Decreasing Severity of Levodopa-induced Dyskinesia
Dopamine receptors are internalized into the cells once stimulated by their agonist in physiological conditions. The applicants have recently shown that, in the context of levodopa-induced dyskinesias...
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Target Validation, 2006Chemical Deorphaning of GPR88: A Candidate Modulator of Motor Function
Dopamine replacement therapy for Parkinson's disease activates neurons in a particular region of the brain, the striatum, leading to an improvement in disease symptoms. This action occurs through a...
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Target Validation, 2006Estrogenic Neuroprotection and the Parkinson's Disease Phenotype
Epidemiological and clinical studies have demonstrated that the prevalence of Parkinson's disease is 1.3 - 3.7 times greater in men than women. In support of this, several studies have also shown that...
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Target Validation, 2006Lowering Alpha-synuclein In Vivo: A Biological Target for PD Treatment
The goal of the proposed work is to pursue efforts in drug development for Parkinson's disease that are aimed at the underlying cause. The recent discoveries of individual genes that are linked to the...
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Target Validation, 2006Development of Novel Phosphodiesterase Inhibitors for the Symptoms & Side Effects Treatment of Parkinson's Disease
The progressive death of brain neurons containing the neurochemical dopamine is the hallmark of Parkinson's disease. The symptoms of PD can be improved by levodopa, a drug which transiently restores...
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Clinical Discovery Awards, 2006The oscillation of basal ganglia
Parkinson's disease (PD) is related to abnormal functioning of an area of the brain known as the basal ganglia. A model of how the basal ganglia works, known as the rate model, proposed about 15 years...
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Our funding programs support basic, translational and clinical research from academia and industry.