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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2021
    Development of an Anti-inflammatory Drug for the Treatment of Parkinson’s Disease

    Study Rationale: Persistent activation of the immune cells that reside in the brain leads to a state of chronic inflammation that contributes to the degeneration of neurons in Parkinson’s disease (PD)...

  • Research Grant, 2021
    Preclinical Testing of a Novel Tracer for Imaging Alpha-synuclein Aggregates

    Study Rationale: In Parkinson's disease (PD), the protein alpha-synuclein is structurally altered such that clumps of alpha-synuclein accumulate in the brain. These aggregates impair the function of...

  • Target Advancement Program, 2021
    Enhancing Treatment Efficacy by Eliminating L-dopa Metabolizing Gut Bacteria

    Study Rationale: Levodopa (L-dopa) is the primary medication used to treat Parkinson’s disease (PD). For L-dopa to exert its effect, it must enter the brain and be converted to the chemical dopamine...

  • Research Grant, 2021
    Development of Selective PET Imaging Agents for Alpha-synuclein and Tau

    Study Rationale: The ability to detect and monitor the accumulation of tau and alpha-synuclein aggregates in the brain is crucial to better understanding the pathophysiology of Progressive...

  • Outcome Measures, 2021
    Assessing Parkinson’s at Home: Contactless Monitoring of Sleep, Motor Symptom Progression and Medication Response

    Study Rationale:
    The ability to accurately monitor Parkinson’s disease (PD) progression and medication response at home can significantly benefit disease management and drug development. In the past...

  • Improved Outcome Measures, 2021
    Development of PD Biomarkers Using Focused Ultrasound-based Noninvasive Biopsy

    Study Rationale: There is an urgent need to develop non-invasive biomarkers that are able to diagnose and track the progression of Parkinson’s disease (PD). Focused ultrasound blood brain barrier...

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