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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Fall 2021 RFP: Accelerating Early Proof-of-Concept Testing of Promising PD Therapies, 2021
    Using Nanobodies and Peptide Mimetics to Stabilize and Activate Mutant GBA

    Study Rationale:    
    Mutations in the gene encoding the enzyme GBA1 are among the most common genetic risk factors for Parkinson’s disease (PD). These mutations compromise the stability and activity...

  • Expanding Biological Understanding of PD, 2021
    Illuminating the Dark Genome of Parkinson’s Disease

    Study Rationale:
    Over the past two decades, the discovery of dozens of genes involved in Parkinson’s disease (PD) has provided a tremendous opportunity to better understand how the disorder develops...

  • PIPETTE 4R Tau and Alpha-Synuclein PET Tracer Development, 2021
    Development of Selective Markers for Imaging Abnormal Protein Aggregates in Parkinson’s Disease

    Study Rationale: 
    In neurological disorders such as Parkinson’s disease (PD) or frontotemporal dementia, the proteins alpha-synuclein or tau are structurally altered and accumulate in clumps in the...

  • Target Advancement Program, 2021
    Pre-clinical Validation of a Novel Target for Dyskinesia Induced by Levodopa

    Study Rationale:
    The motor symptoms associated with Parkinson’s disease (PD) are treated by replacing dopamine, the brain chemical that is lost when dopamine-producing neurons die. Initially...

  • Research Grant, 2021
    Developing a Diagnostic Test to Detect the Signature Scent of Parkinson’s Disease

    Study Rationale:
    People with Parkinson’s disease (PD) emit a novel odor that can be detected months to years before the onset of symptoms. The molecules responsible for this characteristic scent are...

  • Research Grant, 2021
    Bipolar Disorder and Parkinson’s Disease

    Study Rationale:
    Mood disorders are common in people with Parkinson’s disease (PD) and, in many cases, precede motor symptoms and diagnosis by years. The relationship between bipolar disorder and PD...

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