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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Advancement Program, 2021
    Modulation of Epigenetic Regulator HDAC4 as a Parkinson’s Treatment

    Study Rationale:
    Scientists can take skin cells from people with Parkinson’s disease (PD), turn them into stem cells, and then engineer them into dopamine neurons, the cell type lost in PD. Our...

  • Therapeutic Pipeline Program, 2021
    Novel Inhibitors of Protein Aggregation as Potential Therapeutics for Parkinson’s Disease

    Study Rationale: 
    The protein alpha-synuclein can aggregate in brain cells, which leads to brain cell death in Parkinson’s disease (PD). We plan to investigate a novel class of drugs — called protein...

  • Environmental Risk Factors, 2021
    Pesticide Exposure, Systems Biology and Parkinson’s Disease

    Study Rationale:    
    Pesticide exposure is among the most consistently and widely reported environmental risk factors for Parkinson’s disease (PD). However, research on specific pesticides in...

  • Therapeutic Pipeline Program, 2021
    Dietary Interventions to Slow and Improve Parkinson’s Symptoms by Restructuring the Gut Microbiome and Decreasing Inflammation

    Study Rationale:
    There is a link between the gut and the brain in Parkinson’s disease (PD), and gut bacteria may play an important role. Gut bacteria they affect the bowel mucus barrier, produce...

  • Environmental Risk Factors, 2021
    Environmental Risk Factors for Parkinson’s Disease in a Prospective Veteran Cohort

    Study Rationale:    
    Parkinson’s disease may be caused by exposure to toxic substances in the environment, but few of these have been identified. One reason may be that scientists have studied the...

  • Research Grant, 2021
    A New Target for Limiting the Spread of Toxic Alpha-Synuclein Aggregation and Preventing Neuronal Degeneration

    Study Rationale: 
    The pathological hallmark of Parkinson’s disease (PD) is the widespread accumulation of cellular inclusions, called Lewy Bodies, composed of clumps of improperly folded alpha...

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