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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Target Advancement Program, 2021
    Targeting the Neurovascular Unit to Prevent Dissemination and Progression of Parkinson’s Disease

    Study Rationale:    
    The cells residing in the brain are physically separated from the blood stream by the blood-brain barrier, a specialized grouping of cells that reduces transfer from the blood...

  • Access to Data and Biospecimens, 2021
    Assessing Inhibition of a Protein of the “Complement System” to Reduce Brain Inflammation and Neuronal Loss in People with Parkinson’s Disease

    Study Rationale:                   
    Inflammation contributes to the degeneration of neurons in the brains of people with Parkinson’s disease (PD). One of the molecules involved in this inflammatory...

  • Therapeutic Pipeline Program, 2021
    Studies to Assess the Potential of Gold “Nanocrystals” for the Treatment of Parkinson’s Disease

    Study Rationale: 
    CNM-Au8 is a new type of nanomedicine that consists of tiny crystals made of pure gold. The multifaceted surface of these gold nanocrystals provides a platform for metabolic...

  • Target Advancement Program, 2021
    Use of Therapeutic Nanoparticles to Inhibit Toxic Aggregation of Alpha-Synuclein

    Study Rationale:
    A hallmark of Parkinson’s disease (PD) is the abnormal accumulation of clumps of alpha-synuclein in nerve cells. These improperly folded protein clumps contribute to the symptoms of...

  • Research Grant, 2021
    Comparing the Effectiveness of Two Imaging Methods for Monitoring the Progression of Parkinson’s Disease

    Study Rationale:
    Parkinson’s disease robs the brain of dopamine, a neurochemical needed for normal movement and cognition. A variety of imaging methods can be used to monitor the brain’s dopamine...

  • Biomarkers, 2021
    Measurement of Mitochondrial DNA in Early Stages of Parkinson’s Disease

    Study Rationale:    
    People with a form of idiopathic REM sleep behavior disorder (iRBD) experience nightmares and lash out physically during a stage of sleep when the body's muscles are normally...

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