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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Therapeutic Pipeline Program, 2021
    Pharmacological Targeting of Inflammation to Modify Disease Progression in Pre-clinical Models of Parkinson’s Disease

    Study Rationale:
    Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by pronounced brain inflammation. Despite being the most common movement disorder to date, no therapy...

  • Target Advancement Program, 2021
    Exploring the Role of FAIM, an Inhibitor of Cell Death, in Parkinson’s Disease

    Study Rationale:
    Parkinson’s disease (PD) is characterized by the degeneration of dopamine-producing neurons in the brain. We recently discovered that a protein called FAIM can protect neurons from...

  • Therapeutic Pipeline Program, 2021
    Novel Inhibitors of Cell Death for the Treatment of People with Parkinson’s Disease

    Study Rationale: 
    Subcellular structures called mitochondria perform many critical activities for brain cells. They generate enormous amounts of energy and remove the calcium that floods into neurons...

  • Biomarkers, 2021
    The Development of Novel Probes for Imaging Glucocerebrosidase Activity in Parkinson’s Disease

    Study Rationale:       
    Mutations that disable glucocerebrosidase (GBA), a protein that strips sugars from molecules in the membranes of brain cells, are associated with Parkinson’s disease (PD)...

  • Research Grant Supplement, 2021
    Profiling the Removal of Damaged Mitochondria in Stem Cell-Derived Brain Cells from People with Parkinson’s

    Promising Outcomes of Original Grant:
    Our previous work has shown that metabolic failure plays a critical role in the pathology of Parkinson’s disease (PD). A plethora of evidence from different...

  • Priority Biology, 2021
    Gene Expression Changes Induced by Alpha-Synuclein

    Study Rationale: 
    Deposits of the alpha-synuclein protein are the key cellular pathology recognized to drive the progression of Parkinson’s disease leading to the death of neurons. The alpha-synuclein...

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