The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.
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Previously funded studies appear chronologically, with the most recent appearing first.
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Research Grant, 2020Biomarker for Mitophagy Pathway Activation
Study Rationale:
Abnormal PINK1-PRKN directed mitochondrial quality control appears to be an important contributor to Parkinson’s disease (PD). Measures to assess activation of this pathway in... -
Research Grant Supplement, 2020Developing Biosignatures for Parkinson's Disease Using Sense of Smell (Supplement)
Study Rationale:
It has been described that people with Parkinson’s disease have a specific signature odor. This odor arises from an oily skin secretion called sebum. Odor detection in the nose is... -
The Role of Inflammation in Parkinson's Disease, 2020The Role of Viral Infection in Immune Dysregulation of Cells in Parkinson’s
Study Rationale:
It has been observed that immune cells from Parkinson’s disease (PD) blood respond to pathogens in a way that promotes inflammation. However, it is unknown whether this... -
Priority Biology, 2020Structural Insights into Activated Intermediates of Parkin Continued
Study Rationale:
Loss of proteins responsible for removing damaged mitochondria (the cell power plants) is the most common cause of young-onset Parkinson’s disease (YOPD). Parkin and PINK1 are key... -
Research Grant, 2020Molecular Basis of Neurodegeneration in GBA-associated Parkinson’s Disease
Study Rationale:
Studies in human genetics have implicated the malfunction of a cellular compartment called the lysosome in the pathogenesis of Parkinson’s and other brain diseases. Lysosomes are... -
Research Grant, 2020Alpha-synuclein Toxicity in LRRK2 Knock-in Models and Rescue by LRRK2 Silencing
Study Rationale:
Gene mutations that alter the function of the LRRK2 protein are known to increase the risk of developing Parkinson’s disease (PD). One of the pathological hallmarks of PD is the...
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Our funding programs support basic, translational and clinical research from academia and industry.