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Funded Studies

The Foundation supports research across basic, translational and clinical science to speed breakthroughs that can lead to the creation of new treatments and a better quality of life for people with Parkinson's disease.

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Previously funded studies appear chronologically, with the most recent appearing first.

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  • Research Grant, 2020
    Molecular Basis of Neurodegeneration in GBA-associated Parkinson’s Disease

    Study Rationale:
    Studies in human genetics have implicated the malfunction of a cellular compartment called the lysosome in the pathogenesis of Parkinson’s and other brain diseases. Lysosomes are...

  • Research Grant, 2020
    Alpha-synuclein Toxicity in LRRK2 Knock-in Models and Rescue by LRRK2 Silencing

    Study Rationale:
    Gene mutations that alter the function of the LRRK2 protein are known to increase the risk of developing Parkinson’s disease (PD). One of the pathological hallmarks of PD is the...

  • Research Grant, 2020
    Studying the Effects of TMEM175 and CTSB on Glucocerebrosidase Activity and Alpha-synuclein Properties

    Promising Outcomes of Original Grant:
    The aim of the original grant was to study if there are genes that modify the risk of Parkinson’s disease (PD) or the age at onset of PD, among people who carry...

  • Research Grant, 2020
    Revisiting Alpha-synuclein Pathology Staging and Detection Using an Expanded Antibodies Toolset

    Study Rationale:
    The levels of alpha-synuclein aggregates and their spreading to different brain region seem to correlate with Parkinson’s disease (PD) progression and symptoms. Increasing evidence...

  • Therapeutic Pipeline Program, 2020
    Novel Candidate against Alpha-synuclein for the Treatment of Parkinson’s Disease

    Study Rationale:
    The goal of this program is to develop a novel drug for Parkinson’s disease with a unique mechanism of action. We have a drug candidate that shows potential as an inhibitor of alpha...

  • Biosample Use Program, 2020
    Identification of Autoantibodies in People at Risk of Developing Parkinson’s Disease Using Microarrays

    Study Rationale:    
    Autoantibodies are antibodies that mistakenly target and react with a person's own tissues or organs. Autoantibodies can be detected many years before symptoms develop in many...

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