This grant builds upon the research from a prior grant: Further evaluation fo the neuroprotective effects of citrus flavenoid tangeretin in a pre-clinical model of PD
Promising Outcomes of Original Grant:
The initial granting period resulted in the successful identification of antibodies capable of targeting and internalizing into novel in vitro blood-brain barrier models. As such, these antibodies represent promising leads for in vivo drug delivery to the brain.
Objectives for Supplemental Investigation:
In this supplemental investigation, it is proposed to further evaluate the identified antibodies for their capacity to home to the brain in vivo after intravenous administration. Antibodies will be mined for those that exhibit favorable properties including brain-specific targeting potential and efficient brain uptake.
Importance of This Research for the Development of a New PD Therapy:
Newly identified brain targeting antibodies will have the potential to allow efficient peripheral delivery of a wide range of drug cargo including gene therapeutics or trophic proteins.