Study Rationale: Parkinson's disease (PD) is a growing global health concern, and recent research suggests that exposure to certain toxic chemicals, such as pesticides, may contribute to its development. However, government agencies, such as the US Environmental Protection Agency (EPA), currently lack robust methods to evaluate and regulate these chemicals effectively, putting the public at risk of developing PD. There is therefore an urgent need for improved scientific tools and regulatory practices to address the impact of toxic chemicals on PD risk.
Hypothesis: We hypothesize that by applying rigorous scientific methodologies to evaluate the association between specific pesticides and PD, we can generate more accurate risk estimates and strengthen regulatory measures to protect public health.
Study Design: First, we will conduct an in-depth case study focusing on paraquat, a neurotoxic pesticide strongly linked to PD. We will comprehensively analyze the scientific evidence linking paraquat exposure to PD and quantify the risk estimates for PD across diverse populations, thereby informing and enhancing the regulation of paraquat. Next, we will establish a framework for integrating data from non-animal tests into regulatory decision-making for organophosphate pesticides, another class of neurotoxic pesticides associated with neurodevelopmental harm. This framework will outline actionable steps for EPA to ensure transparent and scientifically sound evaluation of non-animal test data, facilitating more protective regulations for organophosphate pesticides.
Impact on Diagnosis/Treatment of Parkinson’s disease: By enhancing the accuracy and reliability of risk assessments for pesticides, we aim to reduce environmental exposures that may contribute to PD development. Ultimately, this could lead to improved public health outcomes, including a reduction in the burden of PD and other neurological disorders associated with toxic chemical exposures.
Next Steps for Development: In the next phase of our project, we will disseminate our findings and recommendations through peer-reviewed publications, stakeholder engagement and advocacy efforts. Additionally, we will continue to collaborate with experts and community groups to refine and implement our proposed framework for incorporating non-animal test data into regulatory decision-making.