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MJFF Publications

The Michael J. Fox Foundation continually strives to communicate our scientific progress with the research community — through posters and presentations at meetings, in peer-reviewed scientific publications and with white paper reports.

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    Overview of GBA1 Models

    The most common genetic form of Parkinson’s disease (PD) is caused by heterozygous mutations in the GBA1 gene which encodes the lysosomal enzyme GCase, leading to decreased activity and accumulation…
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    Overview of LRRK2 Models

    The mutations in the LRRK2 gene which increase the LRRK2 kinase activity are a common genetic form of Parkinson’s disease (PD). The most common mutation is the G2019S mutation which increases kinase…
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    Overview of Alpha-Synuclein Models

    As one of the hallmarks of Parkinson’s disease, alpha-synuclein (aSyn) pathology is a highly desired readout in model systems. There are many in vivo models available that use aSyn mutations,…
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    Overview of NLRP3 Models

    NLRP3 has arisen as a target of interest for Parkinson’s disease (PD) given increased levels seen in patient brain and preclinical studies showing inhibition of NLRP3 decreases pathology and motor…
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    The Michael J. Fox Foundation’s development and distribution of novel alpha-synuclein viral vectors to study Parkinson's disease.

    The Michael J. Fox Foundation’s development and distribution of novel alpha-synuclein viral vectors to study Parkinson's disease.  Elisia M. Clark*, Nicole K. Polinski*, Bradford Casey*, Tomas…
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    LRRK2 inhibitors induce reversible changes in nonhuman primate lungs without measurable pulmonary deficits

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    The Michael J. Fox Foundation’s Efforts to Understand the Relationship between GBA1 and Alpha-Synuclein through the Development and Characterization of Preclinical Models

    Heterozygous mutations in the GBA1 gene--which encodes for lysosomal glucocerebrosidase (GCase)--are the most common genetic risk factor for Parkinson’s disease (PD). In addition, decreased GCase…
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Articles authored by Rachel Dolhun, MD, a movement disorder specialist on staff at MJFF, offer a practical review of topics related to Parkinson's disease for practicing clinicians.

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Female researcher pipetting in lab.

Breaking Research Updates

Read the latest developments in the field’s understanding and treatment of Parkinson’s disease.

Read Research News
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