MJFF funded a study to compare multiple common alpha-synuclein mouse models to understand their PD-related phenotypes at 4, 8, and 12 months of age. Lines include Thy-1 aSyn Line 15 Tg (MJFF), Thy-1 aSyn Line 61 Tg (Masliah), WT aSyn BAC (MJFF), A53T aSyn M83 Tg (Lee), A53T aSyn Tg (Nussbaum), A30P/A53T aSyn Tg (Richfield), E46K aSyn BAC (Elan), HOM aSyn KO (MJFF), and HET aSyn KO (MJFF). Readouts include pS129 alpha-synuclein immunostaining, motor behavior readouts, and substantia nigra dopamine neuron stereology.