To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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GBA E326K Knockin Mouse*
Mouse expressing GBA E326K mutation and 3 silent mutations in exon 8 of the mouse Gba gene. Model was generated and deposited by Mark Cookson at NIH through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036159
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MCI-PARK Mouse*
Homozygous knockout mice targeting Ndufs1 (NADH:ubquinone oxidoreductase core subunit S2) specifically in dopaminergic neurons. Mice with floxed Ndufs2 allele were crossed with mice expressing Cre recombinase under the control of Slc6ac (dopamine transporter; DAT) promoter. Model was generated and deposited by D. James Surmeier at Northwestern University through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:036313
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SNCA-GFP Knockin Mouse*
Mouse expressing SNCA with GFP fused to the C-terminus resulting in expression of GFP-tagged alpha-synuclein under the control of endogenous regulatory elements. Model was generated and deposited by Kelvin Luk at University of Pennsylvania through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:035412
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LRRK2 pT1410 Phosphospecific Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine1410 of LRRK2. Antibody is suitable for immunoblotting applications.
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Oligomeric Alpha-Synuclein Protein*
Stable oligomeric aggregates of alpha-synuclein protein. Intended for use in biochemical assays (not intended for use in the pre-formed fibril model).
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Parkin/PINK1 Double KO Rat
Knockout of Parkin and PINK1 in the Long Evans Hooded rat strain.
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Halo-Tagged LRRK2 MEF
Mouse embryonic fibroblast line with knockin of the Halo tag on the N-terminal of LRRK2.
Expected availability: Late 2024
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LRRK2 R1441G KI MEF
Mouse embryonic fibroblast line with knockin of the LRRK2 R1441G mutation.
Expected availability: Late 2024
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic