To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Total PINK1 Antibody
Monoclonal antibody directed against human total PINK1. Suitable for immunoblotting experiments. The antibody was mapped to AA 188-194 with some cross-reaction to AA287-301.
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pS65 Parkin Antibody (WB/ICC)
Rabbit monoclonal phosphospecific antibody directed against Serine65 of Parkin. Compatible with immunoblotting and immunocytochemistry applications.
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AAV1/2-CAG-Scrambled Control 3xSCRmiR/GFP
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and a scrambled control 3XmiR. To be used as a control vector with Mouse SNCA 3xmiR/GFP and Human SNCA 3xmiR/GFP. AAV 3xSCRmiR/GFP plasmid is available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
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Mouse Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Full-length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note, we recommend this protein for in vitro studies but not for in vivo experiments (the protein as validated for pS129 alpha-synuclein pathology in vitro but in vivo validation failed as robust pS129 alpha-synuclein pathology was not observed).
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
*Discontinued for fibrils lack of seeding activity.
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Parkin W402A KI Mouse
CRISPR/Cas9 generated mice carrying the Park2, Parkinson disease (autosomal recessive, juvenile) 2, parkin, W402A point mutation in exon 11.
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029317
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GBA D409V Knockin x Thy1-Alpha-Synuclein Mouse
Transgenic mice resulting from the cross between transgenic mice overexpressing the D409V mutant form of GBA (homozygous) and transgenic mice overexpressing wild type human alpha-synuclein directed by the murine Thy-1 promoter (hemizygous).
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029124
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Alpha-Synuclein Aggregation Assay*
High-throughput in vitro assay to detect alpha-synuclein aggregation developed in a dopamine neuron-like cell line of human origin. Available as a fee-for-service assay.
Generated as part of the Industry Tools Consortium.
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Total DJ-1 Antibody
Mouse monoclonal antibody directed against full length DJ-1. Ideal for use in immunoblotting or immunoassays.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic