To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Ubiquitin pS65 Phosphospecific Antibody (WB/ICC/ELISA)
Rabbit monoclonal phosphospecific antibody directed against Serine65 of ubiquitin. Suitable for immunoblot, immunocytochemistry, and ELISA applications.
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AAV2/5-CBh-eBFP
Viral Vector (AAV2/5 serotype) encoding eBFP to be used as a control for the AAv2/5 WT Human alpha-synuclein viral vector. This virus will not be made available as the QC/QA testing shows that it induces undesired inflammation and toxicity. Since stocks are available, groups may send a request for samples to tools@michaeljfox.org and may be granted access after vetting.
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AAV2/5-CBh-Alpha-Synuclein
Viral Vector (AAV2/5 serotype) encoding wild-type human alpha-synuclein. AAV2/5-CBh-empty vector control is available as a control (listed in the Other gene/protein type section) and the AAV-CBh-alpha-synuclein plasmid is available in the Plasmid section.
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HdAd5 3xFLAG-TK
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged TK. For use as a control with the HdAd5 3xFLAG-LRRK2 (WT, G2019S, G2385R) viral vectors.
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AAV1/2-CAG-Human SNCA 3xmiR/GFP
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT human a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Human SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
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AAV1/2-CAG-Mouse SNCA 3xmiR/GFP
CNS optimized viral vector (AAV1/2 pseudotype) encoding GFP and 3XmiR to alpha-synuclein for specific knockdown of WT mouse a-syn and common pathogenic mutant forms (A53T, A30P, E46K). Scrambled Control 3xSCRmiR/GFP available as a control in Reporter section and AAV Mouse SNCA 3xmiR/GFP plasmid available in the Plasmid section.
Generated as part of the Industry Tools Consortium.
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LRRK1/2 Double KO Rat*
Double knockout of the genes encoding LRRK1 and LRRK2 in the Long Evans Hooded rat strain. RRID:RGD_7241053
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PINK1 KO Rat*
Homozygous rat knockout of Pink1 (PTEN-induced putative kinase 1) in the Long Evans Hooded rat strain. RRID:RGD_7241054
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic