To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Alpha-Synuclein A53T Knockin Rat
CRISPR/Cas9 genome targeting strategy to knockin humanized amino acids for A53T on a Sprague Dawley rat aSyn KO background. RRID:RGD_13782163
Generated as part of the Industry Tools Consortium.
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LRRK2 Antibody (SIG-39840)
Mouse monoclonal antibody generated in a mouse lacking endogenous LRRK2 protein using a peptide of LRRK2 (AA 2069-2087).
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LRRK2 R1441G Mouse
Transgenic mice overexpressing a mutant form (R1441G) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018786
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Alpha-Synuclein KO Rat
Sprague Dawley rat strain with CRISPR/Cas9 genome targeting strategy to KO endogenous alpha-synuclein.
Generated as part of the Industry Tools Consortium.
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LRRK2 Antibody (N241A/34)
Mouse monoclonal antibody directed against wild-type LRRK2 using a fragment of LRRK2 (AA 970-2527).
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Total Rab 8 Antibody (Hu)
Rabbit monoclonal antibody directed against the human total Rab 8 protein. Suitable for immunoblot, immunostaining, flow cytometry, and immunoprecipitation experiments. Epitope was mapped to amino acids 189-199.
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Full Length pS129 Alpha-Synuclein Protein
Phospho-S129 Alpha Synuclein semi-synthetic phosphomimetic protein generated by native chemical ligation of a recombinant peptide produced from E. coli and a synthtic peptide
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Total Rab 8 Antibody (Hu/Ms/Rt)
Rabbit monoclonal antibody directed against the human and rodent total Rab 8 protein. Suitable for immunoblot and immunoprecipitation experiments. This antibody epitope was mapped to C-terminus amino acids 190-196.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic