To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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* = MJFF does not control pricing or terms of availability for this tool.
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Rab 12 pS106 Phosphospecific Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse Rab12 phospho-S106 for immunoprecipitation and immunostaining applications.
Estimated Availability: Early 2025
LRRK2 pT2483 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine 2483 of LRRK2.
Thy-1 Wild Type Human Alpha-Synuclein Mouse (Line 61)*
Mouse Model
Transgenic mice expressing wild type human alpha-synuclein cDNA driven by the mouse Thy1 promoter. Model was developed by Eliezer Masliah and deposited by Robert Rissman at University of California San Diego, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038796
PDGFβ-Human Alpha Synuclein (Line D) Mouse*
Mouse Model
Mice express wildtype human alpha synuclein cDNA driven by the platelet derived growth factor, β polypeptide (PDGFB) promoter. Model was developed by Eliezer Masliah and deposited by Robert Rissman at University of California San Diego, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038774
Mouse Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note, we recommend this protein for in vitro studies but not for in vivo experiments (the protein is validated for pS129 alpha-synuclein pathology in vitro but in vivo validation failed as robust pS129 alpha-synuclein pathology was not observed). These highly pure proteins are recommended for biochemical studies and can be used to form fibrils, but these fibrils have been found to lack seeding activity.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
S69R Rab32 KI Mouse
Mouse Model
CRISPR/Cas9 genome targeting strategy to knockin S69R point mutation in the endogenous mouse Rab32 gene (corresponds to the S71R mutation in human Rab32).
Estimated Availability: Early 2025
Rab 10 Protein
Protein
Rab10 semi-synthetic phosphomimetic protein fragment (AA66-181) generated by native chemical ligation of recombinant peptides. To be used as a control with the pT73 Rab1o protein.
Rab 12 Antibody (IP)
Antibody
Rabbit monoclonal antibody directed against human Rab 12. Suitable for use in immunoprecipitation.
Total Rab 29 Antibody (Hu)
Antibody
Rabbit monoclonal antibody directed against the human total Rab 29 protein. Suitable for immunoblot and immunoprecipitation experiments. This antibody epitope was mapped to amino acids 141-150.
LRRK2 Wild-type Mouse
Mouse Model
Mice express a wild-type human LRRK2 gene directed by its endogenous promoter/enhancer regions on the BAC transgene. The human LRRK2 protein expression is approximately 5-fold over endogenous mouse LRRK2. RRID:IMSR_JAX:013725
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic