To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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AAV5-CBA-Alpha-Synuclein
Viral Vector
Viral vector (AAV5 serotype) encoding wild-type alpha-synuclein. Produced by the UNC Vector Core. AAV5-CBA-eGFP available as a control in Control section.
Characterization data for this viral vector can be found here.
AAV2-CBA-eGFP
Viral Vector
Viral vector (AAV2 serotype) encoding eGFP to serve as a control vector. Produced by the UNC Vector Core.
Characterization data for this viral vector can be found here.
AAV5-CBA-eGFP
Viral Vector
Viral vector (AAV5 serotype) encoding eGFP to serve as a control vector. Produced by the UNC Vector Core.
Characterization data for this viral vector can be found here.
AAV2-CBA-Alpha-Synuclein
Viral Vector
Unavailable. Viral vector (AAV2 serotype) encoding wild-type alpha-synuclein. Produced by the UNC Vector Core.
Characterization data for this viral vector can be found here.
Alpha-Synuclein KO Mouse
Mouse Model
Homozygous knockout of alpha-synuclein created by deletion of SNCA exons 1-4 in the C57BL/6N mouse strain. RRID:IMSR_JAX:016123
Alpha-Synuclein pS129 Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 129 of alpha-synuclein.
DNAJ26 Plasmids
DNA Plasmids
DNA Plasmids encoding various DNAJ26 cDNA inserts
DJ-1 Plasmids
DNA Plasmids
DNA Plasmids encoding various DJ-1 cDNA inserts
Eif4g1 KO
Mouse Model
Mice carrying a targeted Eif4g1 mutation in which exons 24 through 28 are deleted. RRID:IMSR_JAX:024521
Human Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-Length human alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. These highly pure proteins are recommended for biochemical studies and can be used to form fibrils, but these fibrils have been found to lack seeding activity.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic