To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
Human Alpha-Synuclein Mouse*
Mouse Model
Homozygous knockout of endogenous wild type mouse alpha-synuclein, with BAC expression of the full human alpha synuclein gene and 34kb of its upstream region. Model was generated and deposited by Robert Nussbaum at University of California San Francisco through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:010710
Human Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-Length human alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
*Discontinued for fibrils lack of seeding activity.
Human Alpha-Synuclein Plasmid for PFFs
DNA Plasmids
Plasmid used for bacterial expression of human monomeric alpha-synuclein for the PFF-compatible protein distributed by Proteos (see Protein section). RRID:Addgene_51486
LRRK1/2 Double KO Mouse
Mouse Model
Double knockout of LRRK1 and LRRK2 created by deletion of exons 39-40 of the LRRK2 gene and exons 24-29 of the LRRK1 gene in the C57BL/6N mouse strain. RRID:IMSR_JAX:016122
LRRK1 KO Mouse
Mouse Model
Knockout of LRRK1 created by deletion of exons 24-29 of the LRRK1 gene in the C57BL/6N mouse strain. RRID:IMSR_JAX:016120
LRRK2 Antibody (MJFF5)
Antibody
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
LRRK2 Antibody (MJFF2)
Antibody
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
LRRK2 Antibody (MJFF3)
Antibody
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
LRRK2 Antibody (MJFF4)
Antibody
Rabbit monoclonal antibody directed against wild-type LRRK2. The antibody was mapped to the LRR domain of LRRK2 (AA 1035-1239).
LRRK2 A2016T Mouse
Mouse Model
Mice expressing the A2016T mutant (kinase inhibitor resistant) form of LRRK2. RRID:IMSR_JAX:021828
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic