![Illustrated close up of DNA.](/sites/default/files/styles/hero_xl/public/images/hero/Artboard1-80.jpg?h=1771c8c6&itok=-j_OtRem)
![Illustrated close up of DNA.](/sites/default/files/styles/hero_xl/public/images/hero/Artboard1-80.jpg?h=1771c8c6&itok=-j_OtRem)
To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
-
Sponsored Tools Program
Learn more about how MJFF can help share your tools.
-
Tools Consortium
MJFF is working with industry to develop priority tools.
-
Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
TH-GFP Rat (non-X-linked)
Rat Model
Rats expressing green fluorescent protein (GFP) under the rat tyrosine hydroxylase (TH) promotor. This is a non-X-linked mutation.
TH- GFP Rat (X-linked)
Rat Model
AAV1/2-CAG-A53T Alpha-Synuclein
Viral Vector
Viral Vector (AAV1/2 serotype) encoding alpha-synuclein with the A53T mutation. AAV1/2 empty vector available as a control in Reporter section and the AAV-CAG-A53T alpha-synuclein plasmid is available in the Plasmid section.
Alpha-Synuclein Preformed Fibril Protein*
Protein
Aggregated alpha-synuclein protein intended for use in synuclein seeding experiments.
GBA D409V Knockin x Thy1-Alpha-Synuclein Mouse
Mouse Model
Transgenic mice resulting from the cross between transgenic mice overexpressing the D409V mutant form of GBA (homozygous) and transgenic mice overexpressing wild type human alpha-synuclein directed by the murine Thy-1 promoter (hemizygous).
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029124
Oxidized-DJ-1-Specific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against oxidized DJ-1 protein.
Cell line stably expressing mutant LRRK2 D2017A/G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a D2017A and G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cell line stably expressing mutant LRRK2 G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cell line stably expressing mutant LRRK2 T1348N (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a T1348N mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
Cell line stably expressing wildtype LRRK2 (Type: Raw 264.7 macrophages)
Immortalized Cell
Wildtype LRRK2 parental Raw 264.7 macrophage cell line to be used as a control with the mutant LRRK2 T1348N (KI) or LRRK2 (KO) macrophages.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic