To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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HdAd5 3xFLAG-TK
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged TK. For use as a control with the HdAd5 3xFLAG-LRRK2 (WT, G2019S, G2385R) viral vectors.
Humanized SNCA Mouse
Mouse Model
Mouse expressing the full human SNCA gene (including promoter, introns, and regulatory elements) without endogenous murine SNCA. Please note: MJFF was not successful in generating this line after multiple attempts. Alternative BAC human alpha-synuclein mouse lines are available at JAX.
Parkin/PINK1 Double KO Rat
Rat Model
Knockout of Parkin and PINK1 in the Long Evans Hooded rat strain.
Human Alpha-Synuclein A53T Mouse*
Mouse Model
Transgenic mice expressing the A53T missense mutant form of human alpha-synuclein under the control of the murine prion promoter. Model was generated and deposited by Michael Lee at University of Minnesota through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:006823
iPLA2beta Knockout Mouse*
Mouse Model
Mice carrying a Pla2g6 mutation resulting replacement of exon 2 by a NEO cassette. Model was generated and deposited by Zemin Yao at University of Ottawa through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:023542
Oligomeric Alpha-Synuclein Protein*
Protein
Stable oligomeric aggregates of alpha-synuclein protein. Intended for use in biochemical assays (not intended for use in the pre-formed fibril model).
OMP25 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse OMP25 for immunoprecipitation of endogenous mitochondria.
Estimated Availability: Late 2025
Halo-Tagged LRRK2 MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockin of the Halo tag on the N-terminal of LRRK2.
Expected availability: Early 2026
Glucosylceramide Antibody
Antibody
Rabbit monoclonal antibody directed against human/rodent glucosylceramide.
Estimated Availability: Late 2027
INPP5F pS940 Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine 940 of INPP5F.
Estimated Availability: Late 2025
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic