To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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LRRK2 D1994A Mouse
Mouse Model
Mice expressing the D1994A mutant (kinase-dead) form of LRRK2. RRID:IMSR_JAX:021830
LRRK2 D1994A/G2019S Mouse
Mouse Model
Transgenic mice overexpressing both a mutant form D1994A and G2019S of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene.
Please note: Although founders were positively identified through genotyping and exhibited robust mRNA expression, these projects were halted due to a lack of any appreciable protein expression.
LRRK2 D1994A/R1441G Mouse
Mouse Model
Transgenic mice overexpressing both a mutant form D1994A and R1441G of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene.
Please note: Although founders were positively identified through genotyping and exhibited robust mRNA expression, these projects were halted due to a lack of any appreciable protein expression.
LRRK2 Full-Length Protein (Human)
Protein
Full-Length human LRRK2 protein generated in vitro and assessed for kinase activity.
LRRK2 G2019S KI MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockin of the LRRK2 G2019S mutation.
Expected availability: Late 2025
LRRK2 G2019S KI Mouse
Mouse Model
Mice expressing the human G2019S point mutation introduced into exon 41 of the mouse LRRK2 gene.
LRRK2 G2019S Mouse
Mouse Model
Transgenic mice overexpressing a mutant form (G2019S) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018785
LRRK2 G2019S Mouse*
Mouse Model
Transgenic mice expressing full length LRRK2 with G2019S mutation driven by CMV enhancer and PDGFB promoter/enhancer elements. Model was generated and deposited by Darren Moore at Van Andel Research Institute and Valina Dawson at Johns Hopkins University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016575
LRRK2 G2019S Mouse*
Mouse Model
Transgenic mice expressing human LRRK2 G2019S mutation directed by the human LRRK2 promoter/enhancer regions on the BAC transgene. Model was generated and deposited by Chenjian Li at Mount Sinai School of Medicine through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:009609
LRRK2 Knockout Mouse*
Mouse Model
Homozygous LRRK2 knockout mice with the promoter and exon 1 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery).
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic