To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
LRRK2 Knockout Mouse*
Mouse Model
LRRK2 knockout mice with the LRRK2 promoter and exon 1 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016209
LRRK2 Knockout Mouse*
Mouse Model
LRRK2 knockout mice with the LRRK2 exons 29-30 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016210
LRRK2 Knockout Mouse*
Mouse Model
LRRK2 knockout with the LRRK2 exon 41 deleted. Model was generated and deposited by Matthew Farrer at University of British Columbia through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:012444
LRRK2 KO MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockout of LRRK2.
Expected availability: Mid 2025
LRRK2 KO Mouse
Mouse Model
Knockout of LRRK2 created by deletion of exons 39-40 of the LRRK2 gene in the C57BL/6N mouse strain. RRID:IMSR_JAX:016121
LRRK2 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout LRRK2 on a Sprague Dawley rat background.
Estimated Availability: Early 2026
LRRK2 KO Rat*
Rat Model
Homozygous rat knockout of LRRK2 created by 10 base pair deletion in Exon 30 in the Long Evans Hooded rat stain.
LRRK2 N2081D KI Mouse*
Mouse Model
Mice with the N2081D mutation in LRRK2. Model was generated and deposited by Dr Zhenyu Yue at the Icahn School of Medicine at Mount Sinai through the MJFF Sponsored Tools Program.
Estimated Availability: Late 2024
LRRK2 Plasmids
DNA Plasmids
DNA Plasmids encoding various LRRK2 cDNA inserts
LRRK2 pS1292 Phosphospecific Antibody
Antibody
This rabbit monoclonal phosphospecific antibody was directed against human LRRK2 (aa 1250-1350, phospho S1292; the exact sequence is commercially sensitive). This antibody performs well in immunoblotting experiments from cell lysate.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic