To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Acid Ceramidase (ASAH1) Antibody
Antibody
Rabbit monoclonal antibody directed against human acid ceramidase for immunocytochemistry and immunoprecipitation applications.
Alpha Synuclein Gene Replacement A53T (SNCA-GR*A53T) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039167
Alpha Synuclein Gene Replacement E46K (SNCA-GR*E46K) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the E46K mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039168
Alpha Synuclein Gene Replacement WT (SNCA-GR WT) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039166
Alpha-Synuclein 1-119 Truncation Antibody
Antibody
Rabbit monoclonal antibody directed against alpha-synuclein truncated at the 119 residue.
Estimated Availability: Early 2025
Alpha-Synuclein 1-122 Truncation Antibody
Antibody
Rabbit monoclonal antibody directed against alpha-synuclein truncated at the 122 residue.
Estimated Availability: Early 2025
Alpha-Synuclein A30P/A53T Mouse*
Mouse Model
Transgenic mice expressing double mutant form of human alpha synuclein containing A30P and A53T under the control of the rat tyrosine hydroxylase promoter. Model was generated and deposited by Eric Richfield at Rutger’s University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:008239
Alpha-Synuclein A53T Knockin Mouse*
Mouse Model
Double transgenic homozygous mice which have PAC overexpression of human A53T alpha synuclein mutant form on an SNCA knockout mouse background. Model was generated and deposited by Robert Nussbaum at University of California San Francisco through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:010799
Alpha-Synuclein A53T Knockin Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockin humanized amino acids for A53T on a Sprague Dawley rat aSyn KO background. RRID:RGD_13782163
Generated as part of the Industry Tools Consortium.
Alpha-Synuclein Aggregation Assay*
Assay
High-throughput in vitro assay to detect alpha-synuclein aggregation developed in a dopamine neuron-like cell line of human origin. Available as a fee-for-service assay.
Generated as part of the Industry Tools Consortium.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic