To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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SNCA Triplication iPSC line set*
Human iPS Cell
iPSC line derived from a patient with the SNCA triplication mutation. Corrected lines with normal SNCA expression levels and TdTomato reporter KI versions of the lines will also be available. These lines were generated and kindly deposited by Vik Khurana into the MJFF Sponsored Tools Program.
Expected Availability: Late 2025
SNCAbow Mouse*
Mouse Model
Mouse expressing either nuclear localized SNCAWT:TagBFP, SNCAA30P:mTFP1, or SNCAA53T:mKO2 in cre-expressing tissues of the offspring directed by CAG promoter followed by three pairs of orthogonal lox sites (LoxN, Lox2272, and LoxP), and the SNCAbow construct; all targeted into the Gt(ROSA)26Sor locus. Each α-synuclein sequence contains a C-terminal epitope tag: SNCAWT tagged with V5, SNCAA30P tagged with 3XHA, or SNCAA53T tagged with Myc. Model was generated and deposited by Rodger Liddle at Duke University Medical Center through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:037603
SNCA-GFP Knockin Mouse*
Mouse Model
Mouse expressing SNCA with GFP fused to the C-terminus resulting in expression of GFP-tagged alpha-synuclein under the control of endogenous regulatory elements. Model was generated and deposited by Kelvin Luk at University of Pennsylvania through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:035412
STK39 Protein*
Protein
Human STK39 Protein. This protein was generated and shared by Drs Paul Brennan and Karolina Rygiel at Oxford University though the MJFF Sponsored Tools Program.
TH- GFP Rat (X-linked)
Rat Model
TH-GFP Rat (non-X-linked)
Rat Model
Rats expressing green fluorescent protein (GFP) under the rat tyrosine hydroxylase (TH) promotor. This is a non-X-linked mutation.
Thy-1 Wild Type Human Alpha-Synuclein Mouse (Line 15)
Mouse Model
Transgenic mice expressing wild type human alpha-synuclein directed by the murine Thy-1 promoter. Two separate founder lines with different expression levels are available. RRID:IMSR_JAX:017682
Thy-1 Wild Type Human Alpha-Synuclein Mouse (Line 61)*
Mouse Model
Transgenic mice expressing wild type human alpha-synuclein cDNA driven by the mouse Thy1 promoter. Model was developed by Eliezer Masliah and deposited by Robert Rissman at University of California San Diego, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:038796
TMEM115 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse TMEM115 for immunoprecipitation of endogenous golgi.
Estimated Availability: Mid 2026
TMEM175 Antibody
Antibody
Rabbit monoclonal antibody directed against human/mouse TMEM175 for immunoblotting and immunostaining applications.
Estimated Availability: Early 2025
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic