To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Alpha-Synuclein Antibody
Antibody
Mouse anti-alpha-synuclein antibody that has undergone Fc species switching to develop mouse reagents from the original rabbit antibody (MJFR1). The new chimeric antibody is approved for immunoblotting and immunohistochemistry and can be detected using Fc-specific secondary antibodies to mouse IgG.
Alpha-Synuclein Antibody
Antibody
Rabbit monoclonal antibody directed against wild-type human alpha-synuclein. The antibody was mapped to amino acids 118-123 (VDPDNE).
Alpha-Synuclein Filament Protein
Protein
Full-Length human alpha-synuclein protein expressed in vitro and manipulated to form alpha-synuclein filaments.
Note: This filament version of alpha-synuclein was used as antigen for the MJF-14 conformation-specific rabbit monoclonal alpha-synuclein filament-specific antibody which is available at Abcam. This protein is not intended for use as a pre-formed fibril for seeding alpha-synuclein pathology in vivo or in vitro. For protein to use in an alpha-synuclein pre-formed fibril model please use the "Human alpha-synuclein monomer protein for making pre-formed fibrils" available from Proteos.
Alpha-Synuclein Filament-Specific Antibody
Antibody
Conformation-specific rabbit monoclonal antibody directed against the filamentous form of wild-type alpha-synuclein.
Alpha-Synuclein Knockout Mouse*
Mouse Model
SCNA knockout mice carrying a 1164 bp fragment deletion in exon 2. Model was generated and deposited by Vladimir Buchman at Cardiff University School of Biosciences through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:028559
Alpha-Synuclein KO Mouse
Mouse Model
Homozygous knockout of alpha-synuclein created by deletion of SNCA exons 1-4 in the C57BL/6N mouse strain. RRID:IMSR_JAX:016123
Alpha-Synuclein KO Rat
Rat Model
Sprague Dawley rat strain with CRISPR/Cas9 genome targeting strategy to KO endogenous alpha-synuclein.
Generated as part of the Industry Tools Consortium.
Alpha-Synuclein Monomer Protein
Protein
Full-Length human alpha-synuclein monomeric protein generated in vitro.
Note: This protein was used to generate alpha-synuclein filament which was then used as antigen for the MJF-14 alpha-synuclein filament-specific antibody which is also available at Abcam.
Alpha-Synuclein Monomer Protein for PMCA/RT-QuIC Assays
Protein
Recombinant human alpha-synuclein monomeric protein designed to serve as substrate in PMCA/RT-QuIC assays.
Estimated Availability: Late 2025
Generated as part of the Industry Tools Consortium.
Alpha-Synuclein N Terminal Antibody
Antibody
Rabbit monoclonal antibody directed against the N-terminal of human/mouse alpha-synuclein. Epitope has been mapped to amino acids 12-17 and 46-50 (due to sequence homology). Suitable for use in immunoblotting, immunocytochemistry, immunohistochemistry, and immunoassay.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic