To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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BAC-Alpha Synuclein*
Mouse Model
Mice conditionally express wild-type human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028806
BAC-Alpha Synuclein 120*
Mouse Model
Mice conditionally express mutant human synuclein directed by the human SNCA promoter/enhancer regions on the BAC transgene that produces a C-terminal truncated protein. Model was generated and deposited by X. William Yang at University of California Los Angles through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:028808
BAG3 Protein
Protein
Human BAG3 protein. This protein was generated and shared by Drs Paul Brennan and Karolina Rygiel at Oxford University though the MJFF Sponsored Tools Program.
Cathepsin B Protein
Protein
Human Cathepsin B Protein. This protein was generated and shared by Drs Paul Brennan and Karolina Rygiel at Oxford University though the MJFF Sponsored Tools Program.
Cell line stably expressing mutant LRRK2 D2017A/G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a D2017A and G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cell line stably expressing mutant LRRK2 G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cell line stably expressing mutant LRRK2 T1348N (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a T1348N mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
Cell line stably expressing wildtype LRRK2 (Type: Raw 264.7 macrophages)
Immortalized Cell
Wildtype LRRK2 parental Raw 264.7 macrophage cell line to be used as a control with the mutant LRRK2 T1348N (KI) or LRRK2 (KO) macrophages.
Cell line stably lacking LRRK2 expression (KO) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line with a knockout of endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
Conditional R1441G KI Mouse*
Mouse Model
Mice designed for conditional knockin of the LRRK2 R1441G mutation. Model was generated and deposited by Dr Dario Alessi at the University of Dundee through the MJFF Sponsored Tools Program.
Estimated Availability: Late 2025
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic