To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Glucosylceramide Antibody
Antibody
Rabbit monoclonal antibody directed against human/rodent glucosylceramide.
Estimated Availability: Late 2027
GPNMB Protein*
Protein
Human GPNMB Protein. This protein was generated and shared by Drs Paul Brennan and Karolina Rygiel at Oxford University though the MJFF Sponsored Tools Program.
Halo-Tagged LRRK2 MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockin of the Halo tag on the N-terminal of LRRK2.
Expected availability: Early 2026
HdAd5 3xFLAG-LRRK2 (G2019S)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2019S mutation. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-LRRK2 (G2385R)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2385R mutation. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-LRRK2 (wild-type)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged WT LRRK2. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-TK
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged TK. For use as a control with the HdAd5 3xFLAG-LRRK2 (WT, G2019S, G2385R) viral vectors.
Human Alpha-Synuclein A53T Mouse*
Mouse Model
Transgenic mice expressing the A53T missense mutant form of human alpha-synuclein under the control of the murine prion promoter. Model was generated and deposited by Michael Lee at University of Minnesota through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:006823
Human Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-Length human alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. These highly pure proteins are recommended for biochemical studies and can be used to form fibrils, but these fibrils have been found to lack seeding activity.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
Human Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-Length human alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils.
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
*Discontinued for fibrils lack of seeding activity.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic