To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
Filters
Human Alpha-Synuclein Mouse*
Mouse Model
Homozygous knockout of endogenous wild type mouse alpha-synuclein, with BAC expression of the full human alpha synuclein gene and 34kb of its upstream region. Model was generated and deposited by Robert Nussbaum at University of California San Francisco through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:010710
Human Alpha-Synuclein Plasmid for PFFs
DNA Plasmids
Plasmid used for bacterial expression of human monomeric alpha-synuclein for the PFF-compatible protein distributed by Proteos (see Protein section). RRID:Addgene_51486
Human GCase Antibody
Antibody
Rabbit monoclonal antibody directed against human GCase for immunostaining applications. Antibody generation failed.
Human GCase Antibody (ICC)
Antibody
Monoclonal mouse anti-human GCase antibodies (clones 1/17 and 1/23) for immunocytochemistry applications.
These antibodies were generated by Roche and are kindly made available to academic/non-profit organizations only through the MJFF Sponsored Tools Program.
Human iPSC with HiBit-tagged GCase
Human iPS Cell
Human iPSC line with HiBiT tag on the GCase protein and inducible LgBiT expression for live cell imaging and quantitation. Cell line was developed and kindly shared by Dr. Tom Durcan at McGill University through the MJFF Sponsored Tools Program.
Human iPSC with HiBit-tagged GPNMB*
Human iPS Cell
Human iPSC line with HiBiT tag on the GPNMB protein and inducible LgBiT expression for live cell imaging and quantitation. Cell line was developed and kindly shared by Dr. Tom Durcan at McGill University through the MJFF Sponsored Tools Program.
Estimated Availability: Early 2025
Human iPSC with HiBit-tagged LRRK2*
Human iPS Cell
Human iPSC line with HiBiT tag on the LRRK2 protein and inducible LgBiT expression for live cell imaging and quantitation. Cell line was developed and kindly shared by Dr. Tom Durcan at McGill University through the MJFF Sponsored Tools Program.
Human iPSC with HiBit-tagged Parkin*
Human iPS Cell
Human iPSC line with HiBiT tag on the Parkin protein and inducible LgBiT expression for live cell imaging and quantitation. Cell line was developed and kindly shared by Dr. Tom Durcan at McGill University through the MJFF Sponsored Tools Program.
Human iPSC with HiBit-tagged SNCA*
Human iPS Cell
Human iPSC line with HiBiT tag on the alpha-synuclein protein and inducible LgBiT expression for live cell imaging and quantitation. Cell line was developed and kindly shared by Dr. Tom Durcan at McGill University through the MJFF Sponsored Tools Program.
Human iPSC with HiBit-tagged VPS13C*
Human iPS Cell
Human iPSC line with HiBiT tag on the VPS13C protein and inducible LgBiT expression for live cell imaging and quantitation. Cell line was developed and kindly shared by Dr. Tom Durcan at McGill University through the MJFF Sponsored Tools Program.
Estimated Availability: Early 2o25
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic