To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
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DJ-1 proteins (recombinant proteins generated using an E. Coli expression system)
Protein
The following versions of recombinant DJ-1 protein generated using an E. coli expression system are available:
- Untagged DJ-1
- His-tagged DJ-1
- Oxidized DJ-1
FLAG LRRK2 G2019S Mouse*
Mouse Model
Mice expressing FLAG-LRRK2-G2019S transgene directed by the endogenous LRRK2 promoter/enhancer regions on the BAC transgene. Model was generated and deposited by Zhenyu Yue at Mount Sinai School of Medicine through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:012467
HdAd5 3xFLAG-LRRK2 (G2019S)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2019S mutation. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-LRRK2 (G2385R)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged LRRK2 with the G2385R mutation. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-LRRK2 (wild-type)
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged WT LRRK2. HdAd5 FLAG-TK available as a control in Control section.
HdAd5 3xFLAG-TK
Viral Vector
Helper-dependent Adenovirus 5 viral vector with human synapsin promoter driving the expression of 3XFLAG-tagged TK. For use as a control with the HdAd5 3xFLAG-LRRK2 (WT, G2019S, G2385R) viral vectors.
Cell line stably expressing mutant LRRK2 D2017A/G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a D2017A and G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cell line stably expressing mutant LRRK2 G2019S (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a G2019S mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
We were unable to generate this cell line due to technical difficulty and have discontinued production.
Cell line stably expressing mutant LRRK2 T1348N (KI) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line expressing a T1348N mutation in LRRK2 knocked into the endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
Cell line stably lacking LRRK2 expression (KO) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line with a knockout of endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic