To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Parkin W402A KI Mouse
Mouse Model
CRISPR/Cas9 generated mice carrying the Park2, Parkinson disease (autosomal recessive, juvenile) 2, parkin, W402A point mutation in exon 11.
Generated as part of the Industry Tools Consortium. RRID:IMSR_JAX:029317
Rat Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length rat alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note: Validation of the rat alpha-synuclein monomers for making pre-formed fibrils identified a lack of pathology in vitro in mouse primary hippocampal neurons and in vivo in rat. Email tools@michaeljfox.org with questions or for more information.
Mouse Alpha-Synuclein Monomer Protein for Making Pre-Formed Fibrils
Protein
Full-length mouse alpha-synuclein monomeric protein specially formulated to generate pre-formed fibrils. Please note, we recommend this protein for in vitro studies but not for in vivo experiments (the protein as validated for pS129 alpha-synuclein pathology in vitro but in vivo validation failed as robust pS129 alpha-synuclein pathology was not observed).
Note: A protocol for generating pre-formed fibrils from this monomeric protein will be included with each order.
*Discontinued for fibrils lack of seeding activity.
Total Rab 35 Antibody
Antibody
Monoclonal antibody directed against total Rab35 protein. Suitable for immunoblot experiments.
Total Rab 10 Antibody
Antibody
Mouse monoclonal antibody directed against the human total Rab 10 protein. This antibody has been validated for immunoblotting experiments. This antibody epitope was mapped to amino acids 127-133.
pS65 Parkin Antibody (WB/ICC)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine65 of Parkin. Compatible with immunoblotting and immunocytochemistry applications.
LRRK2 pS910 Phosphospecific Antibody (UDD1)
Antibody
Rabbit monoclonal phosphospecific antibody directed against Serine910 of LRRK2.
Total PINK1 Antibody
Antibody
Monoclonal antibody directed against human total PINK1. Suitable for immunoblotting experiments. The antibody was mapped to AA 188-194 with some cross-reaction to AA287-301.
Total Parkin Antibody
Antibody
Monoclonal mouse antibody directed against human Parkin. Suitable for immunoblot experiments.
LRRK2 pT1357 Phosphospecific Antibody
Antibody
Rabbit monoclonal phosphospecific antibody directed against Threonine1357 of LRRK2. Antibody is suitable for immunoblotting application after immunoprecipitating for LRRK2.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic