To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
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* = MJFF does not control pricing or terms of availability for this tool.
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Alpha Synuclein Gene Replacement A53T (SNCA-GR*A53T) Mouse*
Mouse Model
Knock-in/knock-out gene replacement model with mouse genomic regions from Snca exchanged for 158 kb of the human SNCA genomic region including the A53T mutation. Model was donated by Dr. Michael Koob at University of Minnesota, and made available through the MJFF Sponsored Tools Program. RRID:IMSR_JAX:039167
AAV2/5-CBh-eBFP
Viral Vector
Viral Vector (AAV2/5 serotype) encoding eBFP to be used as a control for the AAv2/5 WT Human alpha-synuclein viral vector. This virus will not be made available as the QC/QA testing shows that it induces undesired inflammation and toxicity. Since stocks are available, groups may send a request for samples to tools@michaeljfox.org and may be granted access after vetting.
DOX-Inducible iPSC-Derived Dopamine Neuron
Human iPS Cell
Inducible iPSC line in which addition of doxicycline to the media stimulates differentiation into dopamine neurons with 90% purity in a matter of days.
Estimated Availability: Mid 2026
AAV2/5-CBh-Alpha-Synuclein
Viral Vector
Viral Vector (AAV2/5 serotype) encoding wild-type human alpha-synuclein. AAV2/5-CBh-empty vector control is available as a control (listed in the Control gene/protein type section) and the AAV-CBh-alpha-synuclein plasmid is available in the Plasmid section.
AAV2/5 CBh Empty Vector Control
Viral Vector
Viral Vector (AAV2/5 serotype) to serve as a control vector for the AAV2/5-CBh-WT human alpha-synuclein viral vector. The AAV-CBh-empty vector plasmid is also available in the Plasmid section.
AAV Human SNCA 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV Human SNCA 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194247
AAV1/2 empty vector control
DNA Plasmids
Viral transgene plasmid used in the AAV empty vector control viral vector for the AAV A53T alpha-synuclein viral vector, both available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194243
AAV Scrambled Control 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV scrambled control 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194249
AAV1/2 A53T Alpha-Synuclein Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV1/2 A53T alpha-synuclein viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit and for-profit groups. RRID:Addgene_194242
AAV Mouse SNCA 3xmiR/GFP Plasmid
DNA Plasmids
Viral transgene plasmid used in the AAV Mouse SNCA 3xmiR/GFP viral vector available through Charles River Labs (see viral vector section). This plasmid is available to non-profit groups only. RRID:Addgene_194248
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic