To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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LRRK2 KO Rat
Rat Model
CRISPR/Cas9 genome targeting strategy to knockout LRRK2 on a Sprague Dawley rat background.
Estimated Availability: Early 2026
LRRK2 KO Rat*
Rat Model
Homozygous rat knockout of LRRK2 created by 10 base pair deletion in Exon 30 in the Long Evans Hooded rat stain.
LRRK2 KO Mouse
Mouse Model
Knockout of LRRK2 created by deletion of exons 39-40 of the LRRK2 gene in the C57BL/6N mouse strain. RRID:IMSR_JAX:016121
LRRK2 KO MEF
Immortalized Cell
Mouse embryonic fibroblast line with knockout of LRRK2.
Expected availability: Mid 2025
LRRK2 Knockout Mouse*
Mouse Model
Homozygous LRRK2 knockout mice with the promoter and exon 1 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery).
LRRK2 Knockout Mouse*
Mouse Model
LRRK2 knockout mice with the LRRK2 promoter and exon 1 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016209
LRRK2 Knockout Mouse*
Mouse Model
LRRK2 knockout mice with the LRRK2 exons 29-30 deleted. Model was generated and deposited by Jie Shen at Harvard Medical School Brigham and Women’s Hospital through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016210
LRRK2 Knockout Mouse*
Mouse Model
LRRK2 knockout with the LRRK2 exon 41 deleted. Model was generated and deposited by Matthew Farrer at University of British Columbia through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:012444
LRRK2 G2019S Mouse
Mouse Model
Transgenic mice overexpressing a mutant form (G2019S) of human LRRK2 directed by its endogenous promoter/enhancer regions on the BAC transgene. RRID:IMSR_JAX:018785
LRRK2 G2019S Mouse*
Mouse Model
Transgenic mice expressing full length LRRK2 with G2019S mutation driven by CMV enhancer and PDGFB promoter/enhancer elements. Model was generated and deposited by Darren Moore at Van Andel Research Institute and Valina Dawson at Johns Hopkins University through the MJFF Sponsored Tools Program (available through cryorecovery). RRID:IMSR_JAX:016575
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic