To save researchers time and resources, The Michael J. Fox Foundation has made a number of tools available to the scientific community at low cost, with rapid delivery.
Helpful Resources
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Sponsored Tools Program
Learn more about how MJFF can help share your tools.
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Tools Consortium
MJFF is working with industry to develop priority tools.
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Preclinical Models
Learn more about the various in vivo models used in Parkinson's disease research.
Find a Research Tool
Filter by Tool Type or Gene/Protein Type to Organize Results
* = MJFF does not control pricing or terms of availability for this tool.
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Eif4g1 KO
Mouse Model
Mice carrying a targeted Eif4g1 mutation in which exons 24 through 28 are deleted. RRID:IMSR_JAX:024521
DOX-Inducible iPSC-Derived Dopamine Neuron
Human iPS Cell
Inducible iPSC line in which addition of doxicycline to the media stimulates differentiation into dopamine neurons with 90% purity in a matter of days.
Estimated Availability: Mid 2026
DNAJ26 Plasmids
DNA Plasmids
DNA Plasmids encoding various DNAJ26 cDNA inserts
DJ-1 proteins (recombinant proteins generated using an E. Coli expression system)
Protein
The following versions of recombinant DJ-1 protein generated using an E. coli expression system are available:
- Untagged DJ-1
- His-tagged DJ-1
- Oxidized DJ-1
DJ-1 proteins (recombinant proteins generated in a mammalian-optimized expression system)
Protein
The following versions of recombinant DJ-1 protein generated using a mammalian-optimized expression system are available:
- His-tagged DJ-1
- TEV-cleaved DJ-1
DJ-1 Plasmids
DNA Plasmids
DNA Plasmids encoding various DJ-1 cDNA inserts
DJ-1 KO Rat*
Rat Model
Homozygous rat knockout of DJ-1 created by 8 base pair deletion plus 1 base pair substitution in Exon 5 in the Long Evans Hooded rat strain. RRID:RGD_7241048
Conditional R1441G KI Mouse*
Mouse Model
Mice designed for conditional knockin of the LRRK2 R1441G mutation. Model was generated and deposited by Dr Dario Alessi at the University of Dundee through the MJFF Sponsored Tools Program.
Estimated Availability: Late 2025
Cell line stably lacking LRRK2 expression (KO) (Type: Raw 264.7 macrophages)
Immortalized Cell
RAW 264.7 macrophage cell line with a knockout of endogenous mouse LRRK2 protein using zinc-finger nuclease (ZFN)-assisted adeno viral vector (AAV) technology to generate a stable cell line.
Cell line stably expressing wildtype LRRK2 (Type: Raw 264.7 macrophages)
Immortalized Cell
Wildtype LRRK2 parental Raw 264.7 macrophage cell line to be used as a control with the mutant LRRK2 T1348N (KI) or LRRK2 (KO) macrophages.
Have questions or need additional information?
Email tools@michaeljfox.org with questions and to suggest new tools for us to develop. Or visit our FAQ page.
"We have shown, thanks in part to MJFF, that researchers now have in their pantry the right ‘ingredients’, to... help to drive forward PD drug development.”
Heather Melrose, PhD
Mayo Clinic